Transplantation of tissue-engineering trachea as alternative to allogenic trachea

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چکیده

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[Tissue engineering applied to the trachea as a graft].

Tissue engineering offers, through new technologies, an ex vivo generation of organs and functional tissues as grafts for transplants, for the improvement and substitution of biological functions, with an absence of immunological response. The treatment of extended tracheal lesions is a substitution of the affected segment; nevertheless, the allogeneic transplant has failed and the use of synth...

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Tissue Engineering of the Trachea: What is the Hold-up?

Tissue-engineering of the trachea is called for based on the clinical consequences of airway pathology. Recent years have witnessed various reports from the tissueengineering field including a few cases of clinical patients receiving an engineered airway. Multiple fields have accelerated in parallel with the concept of tissue decellularization, isolation of stem cells and possible insights in t...

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Tissue-engineered trachea for airway reconstruction.

OBJECTIVES/HYPOTHESIS Scaffold-free cartilage has been used to engineer biocompatible and mechanically stable neotracheas in vivo. The purpose of this animal study was to determine if neotracheal constructs, implanted paratracheally, could successfully be used for segmental tracheal reconstruction. STUDY DESIGN Animal study. METHODS Culture-expanded auricular rabbit chondrocytes were used t...

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Reconstruction of the trachea.

Advances in surgical technique and in anaesthesia have made possible a more radical attack on lesions affecting the trachea. Although the number of patients presenting with such a tracheal lesion is small, it is important that they should be treated adequately. Tracheal reconstruction is indicated both for benign and for malignant neoplasms, most of which are found to arise in the lower third. ...

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Surgery of the Trachea

Surgical procedures on the trachea have only been undertaken within the past 50 years. Knowing the unique blood supply of the trachea and how to reduce tension on any anastomosis are key to a successful outcome. Tracheal conditions requiring surgery usually present with shortness of breath on exertion, and preoperative evaluation involves computed tomography and rigid bronchoscopy. Tracheal res...

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ژورنال

عنوان ژورنال: Grekov's Bulletin of Surgery

سال: 2017

ISSN: 2686-7370,0042-4625

DOI: 10.24884/0042-4625-2017-176-4-110-114